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The multiparametric MRI technology underpinning LiverMultiScan™ was first published in two landmark papers from the University of Oxford, highlighting the utility for non-invasive diagnosis and staging of liver disease (Banerjee, R. et al. 2014-J. Hepatol) and prediction of clinical outcomes in patients with chronic liver disease (Pavlides, 2016-J. Hepatol.). Subsequent publications have demonstrated utility in fatty liver disease (Pavlides, 2016-Liver Int., Wilman, 2017, Eddowes, 2018) along with cost-effectiveness when incorporated into a clinical pathway (Blake, 2016).

In earlier posted publications there is mention of a LIF score which is a composite measure based on cT1, a metric provided by LiverMultiScan. LIF is a mapping of cT1 onto a 0-4 scale. cT1 has replaced LIF as the preferred metric for representing iron-corrected relaxation time of liver tissue. It is a direct metric shown to correlate with fibro-inflammation of liver tissue.

More of our publications are listed below.

Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases (1)


Author: Mojtahed, C. J. Kelly, A. H. Herlihy, S. Kin, H. R. Wilman, A. McKay, M. Kelly, M. Milanesi, S. Neubauer, E. L. Thomas, J. D. Bell, R. Banerjee, M. Harisinghani


Journal: Abdominal Radiology
Publication Year: 2019
Volume/Issue: Volume 44, Issue 1
Pages: 72-84

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Measurement of liver iron by magnetic resonance imaging in the UK Biobank population


Author: Andy McKay, Henry R. Wilman, Andrea Dennis, Matt Kelly, Michael L. Gyngell, Stefan Neubauer, Jimmy D. Bell, Rajarshi Banerjee, E. Louise Thomas 


Journal: PLOS ONE
Publication Year: 2018
Volume/Issue:
Pages:

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The “IDEAL” method for fat quantification and iron-corrected T1 accurately measure the presence and severity of the individual histological features of nonalcoholic steatohepatitis (NASH)


Author: Siddiqui,M, Grawenda, A, Cadrain, R, Collen, R, Steinberg, J, Luketic, V, Dennis, A, Hildick, K, Kelly, MD, Neubauer, S, Banerjee, R and Sanyal, A


Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1322 Abstract 2338

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Stratification of biliary disease with quantitative MRCP (MRCP+)


Author: Woodward, G., Mavar, M., Ridgway, G., Halberstadt, M., McKay, A., Kelly, M., Neubauer, S., Brady, M., Banerjee, R. 


Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1111 Abstract 1952

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Cross-sectional, prospective, evaluation of the utility of Multi-parametric MRI imaging in predicting clinically meaningful outcomes in autoimmune hepatitis


Author: Arndtz K, Hodson J, Eddowes P, Kelly MD, Dennis A, Fiore M, Banerjee R, Neubauer S, Hirschfield GM


Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1116 Abstract 1961

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Multi-parametric MRI imaging in a heterogeneous liver disease: cross-sectional evaluation of a cohort of patients with PSC


Author: Arndtz K, Hodson J, Eddowes P, Kelly M, Dennis A, Fiore M, Green D, Banerjee R, Neubauer S, Hirschfield GM


Journal: Hepatology
Publication Year: 2018
Volume/Issue: Volume 68, Issue 1
Pages: 1090 Abstract 1917

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